Description：

Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Phase 3.

Chemical Information：

Molecular Weight (MW)		441.23
Formula		C17H15BrF2N4O3
CAS No.		606143-89-9
Solubility (25°C) *	DMSO	88 mg/mL warmed (199.44 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

HMG-CoA reductas 11 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2664 mL	11.3320 mL	22.6639 mL
5 mM	0.4533 mL	2.2664 mL	4.5328 mL
10 mM	0.2266 mL	1.1332 mL	2.2664 mL
50 mM	0.0453 mL	0.2266 mL	0.4533 mL

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