Description：

AC480 (BMS-599626) is a selective and efficacious inhibitor of HER1 and HER2 with IC50 of 20 nM and 30 nM, ~8-fold less potent to HER4, >100-fold to VEGFR2, c-Kit, Lck, MET etc. Phase 1.

Chemical Information：

Molecular Weight (MW)		530.55
Formula		C27H27FN8O3
CAS No.		714971-09-2
Solubility (25°C) *	DMSO	113 mg/mL (212.98 mM)
	Water	Insoluble
	Alcohol	20 mg/mL (37.69 mM)

Biological Activity：

Targets IC50

mTOR ~0.1 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.8848 mL	9.4242 mL	18.8484 mL
5 mM	0.3770 mL	1.8848 mL	3.7697 mL
10 mM	0.1885 mL	0.9424 mL	1.8848 mL
50 mM	0.0377 mL	0.1885 mL	0.3770 mL

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