Description：

Baricitinib (LY3009104, INCB028050) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM in cell-free assays, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Phase 3.

Chemical Information：

Molecular Weight (MW)		371.42
Formula		C16H17N7O2S
CAS No.		1187594-09-7
Solubility (25°C) *	DMSO	74 mg/mL (199.23 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

Tie2 0.25 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.6924 mL	13.4618 mL	26.9237 mL
5 mM	0.5385 mL	2.6924 mL	5.3847 mL
10 mM	0.2692 mL	1.3462 mL	2.6924 mL
50 mM	0.0538 mL	0.2692 mL	0.5385 mL

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