Description：

ABT-751 (E7010) binds to the colchicine site on β-tubulin and inhibits polymerization of microtubules, not a substrate for the MDR transporter and is active against cell lines resistant to vincristine, doxorubicin, and cisplatin. Phase 1/2.

Chemical Information：

Molecular Weight (MW)		371.41
Formula		C18H17N3O4S
CAS No.		141430-65-1
Solubility (25°C) *	DMSO	74 mg/mL (199.24 mM)
	Water	Insoluble
	Alcohol	12 mg/mL (32.3 mM)

Biological Activity：

Targets IC50

AKT 4.7 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.6924 mL	13.4622 mL	26.9244 mL
5 mM	0.5385 mL	2.6924 mL	5.3849 mL
10 mM	0.2692 mL	1.3462 mL	2.6924 mL
50 mM	0.0538 mL	0.2692 mL	0.5385 mL

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