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Bardoxolone Methyl

Bardoxolone Methyl

Catalog Number: CC8234 Rank: comment rank 5

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Description:

Bardoxolone Methyl is an IKK inhibitor, showing potent proapoptotic and anti-inflammatory activities; Also a potent Nrf2 activator and nuclear factor-κB (NF-κB) inhibitor.

Chemical Information:

Molecular Weight (MW) 505.69
Formula

 

C32H43NO4

 

CAS No. 218600-53-4
Solubility (25°C) * DMSO 21 mg/mL (41.52 mM)
Water Insoluble
Alcohol Insoluble


Biological Activity:

Targets
IC50
Aβ40 γ secretase ICN
14 nM 4 nM 5 nM


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 1.9775 mL 9.8875 mL 19.7750 mL
5 mM 0.3955 mL 1.9775 mL 3.9550 mL
10 mM 0.1977 mL 0.9887 mL 1.9775 mL
50 mM 0.0395 mL 0.1977 mL 0.3955 mL


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