Description：

Bafetinib (INNO-406) is a potent and selective dual Bcr-Abl/Lyn inhibitor with IC50 of 5.8 nM/19 nM in cell-free assays, does not inhibit the phosphorylation of the T315I mutant and is less potent to PDGFR and c-Kit. Phase 2.

Chemical Information：

Molecular Weight (MW)		576.62
Formula		C30H31F3N8O
CAS No.		859212-16-1
Solubility (25°C) *	DMSO	100 mg/mL (173.42 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

Akt2 Akt1 Akt3 17 nM 32 nM 47 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.7342 mL	8.6712 mL	17.3424 mL
5 mM	0.3468 mL	1.7342 mL	3.4685 mL
10 mM	0.1734 mL	0.8671 mL	1.7342 mL
50 mM	0.0347 mL	0.1734 mL	0.3468 mL

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