Description：

PDGFR inhibitor 1 is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of KIT and PDGFR with potential antineoplastic activity. It also inhibits several other kinases, including VEGFR2, TIE2, PDGFR-beta and CSF1R, thereby further inhibiting tumor cell growth.

Chemical Information：

Molecular Weight (MW)		489.47
Formula		C26H21F2N5O3
CAS No.		1225278-16-9
Solubility (25°C) *	DMSO	97 mg/mL (198.17 mM)
	Water	Insoluble
	Alcohol	9 mg/mL (18.39 mM)

Preparing Stock Solutions

Concentration Volume(DMSO)Mass	1 mg	5 mg	10 mg
1 mM	2.0430 mL	10.2151 mL	20.4303 mL
5 mM	0.4086mL	2.0430 mL	4.0861 mL
10 mM	0.2043 mL	1.0215 mL	2.0430 mL
50 mM	0.0409 mL	0.2043 mL	0.4086 mL

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