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Lacosamide

Catalog Number: CC8896 Rank: comment rank 5

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Description:

Lacosamide is a functionalized amino acid that produces activity in the maximal electroshock seizure (MES) test, that, like some other antiepileptic drugs (AEDs), are believed to act through voltage-gated sodium channels. Lacosamide enhances the slow inactivation of voltage-gated sodium channels without affecting the fast inactivation of voltage-gated sodium channels. This inactivation prevents the channel from opening, helping end the action potential. Many antiepileptic drugs, like carbamazepine or lamotrigine, slow the recovery from inactivation and hence reduce the ability of neurons to fire action potentials.



Chemical Information:

Molecular Weight (MW) 250.29
Formula

 

C₁₃H₁₈N₂O₃

 

CAS No. 175481-36-4
Solubility (25°C) * DMSO ≥ 34 mg/mL
Water
Alcohol




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