Description：

(+)-Bicuculline is a competitive antagonist of GABA_A receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.

Chemical Information：

Molecular Weight (MW)		367.35
Formula		C20H17NO6
CAS No.		485-49-4
Solubility (25°C) *	DMSO	21 mg/mL warmed (57.16 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

SIRT1 38 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.7222 mL	13.6110 mL	27.2220 mL
5 mM	0.5444 mL	2.7222 mL	5.4444 mL
10 mM	0.2722 mL	1.3611 mL	2.7222 mL
50 mM	0.0544 mL	0.2722 mL	0.5444 mL

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