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Description:
YM155 (Sepantronium Bromide) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. Phase 2.
Chemical Information:
Molecular Weight (MW) 443.29 Formula
C20H19BrN4O3
CAS No. 781661-94-7 Solubility (25°C) * DMSO 55 mg/mL (124.07 mM) Water 89 mg/mL (200.77 mM) Alcohol 6 mg/mL (13.53 mM)
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg 1 mM 2.2559 mL 11.2793 mL 22.5586 mL 5 mM 0.4512 mL 2.2559 mL 4.5117 mL 10 mM 0.2256 mL 1.1279 mL 2.2559 mL 50 mM 0.0451 mL 0.2256 mL 0.4512 mL
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