Description：

WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308). Selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold).

Chemical Information：

Molecular Weight (MW)		528.61
Formula		C28H32N8O3
CAS No.		1062161-90-3
Solubility (25°C) *	DMSO	0.5 mg/mL (0.94 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.8918 mL	9.4588 mL	18.9175 mL
5 mM	0.3784 mL	1.8918 mL	3.7835 mL
10 mM	0.1892 mL	0.9459 mL	1.8918 mL
50 mM	0.0378 mL	0.1892 mL	0.3784 mL

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