Description：

URMC-099 is an orally bioavailable, brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively, and also inhibits LRRK2 activity with IC50 of 11 nM.

Chemical Information：

Molecular Weight (MW)		421.54
Formula		C27H27N5
CAS No.		1229582-33-5
Solubility (25°C) *	DMSO	84 mg/mL (199.26 mM)
	Water	Insoluble
	Alcohol	6 mg/mL (14.23 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3723 mL	11.8613 mL	23.7225 mL
5 mM	0.4745 mL	2.3723 mL	4.7445 mL
10 mM	0.2372 mL	1.1861 mL	2.3723 mL
50 mM	0.0474 mL	0.2372 mL	0.4745 mL

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