Description：

AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations(>10 nM), AZD7545 stimulates PDHK4 activity.

Chemical Information：

Molecular Weight (MW)		478.87
Formula		C19H18ClF3N2O5S
CAS No.		252017-04-2
Solubility (25°C) *	DMSO	95 mg/mL (198.38 mM)
	Water	Insoluble
	Alcohol	95 mg/mL (198.38 mM)

Biological Activity：

Targets IC50

Aurora B Aurora C Aurora A 0.198 μM 0.227 μM 0.042 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0882 mL	10.4412 mL	20.8825 mL
5 mM	0.4176 mL	2.0882 mL	4.1765 mL
10 mM	0.2088 mL	1.0441 mL	2.0882 mL
50 mM	0.0418 mL	0.2088 mL	0.4176 mL

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