Description：

TPX-0005 is a novel ALK/ROS1/TRK inhibitor with the IC50 values of 1.01 nM for WT ALK, 1.26 nM for ALK(G1202R), and 1.08 nM for ALK(L1196M); also a potent SRC inhibitor (IC50 5.3 nM).

Chemical Information：

Molecular Weight (MW)		355.37
Formula		C18H18FN5O2
CAS No.		no
Solubility (25°C) *	DMSO	70 mg/mL (196.97 mM)
	Water	Insoluble
	Alcohol	10 mg/mL (28.13 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.8140 mL	14.0698 mL	28.1397 mL
5 mM	0.5628 mL	2.8140 mL	5.6279 mL
10 mM	0.2814 mL	1.4070 mL	2.8140 mL
50 mM	0.0563 mL	0.2814 mL	0.5628 mL

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