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Tozasertib (VX-680, MK-0457)

Tozasertib (VX-680, MK-0457)

Catalog Number: CC1204 Rank: comment rank 5

Size Price Qty
$ 102.00
$ 259.00
$ 329.00
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Description:

Tozasertib (VX-680, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. Phase 2.

Chemical Information:

Molecular Weight (MW) 464.59
Formula

 

C23H28N8OS

 

CAS No. 639089-54-6
Solubility (25°C) * DMSO 93 mg/mL (200.17 mM)
Water Insoluble
Alcohol Insoluble


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.1524 mL 10.7622 mL 21.5244 mL
5 mM 0.4305 mL 2.1524 mL 4.3049 mL
10 mM 0.2152 mL 1.0762 mL 2.1524 mL
50 mM 0.0430 mL 0.2152 mL 0.4305 mL


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