Description：

AZD5363 potently inhibits all isoforms of Akt(Akt1/Akt2/Akt3) with IC50 of 3 nM/8 nM/8 nM in cell-free assays, similar to P70S6K/PKA and lower activity towards ROCK1/2. Phase 2.

Chemical Information：

Molecular Weight (MW)		428.92
Formula		C21H25ClN6O2
CAS No.		1143532-39-1
Solubility (25°C) *	DMSO	86 mg/mL (200.5 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

ACE 1.05 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3314 mL	11.6572 mL	23.3144 mL
5 mM	0.4663 mL	2.3314 mL	4.6629 mL
10 mM	0.2331 mL	1.1657 mL	2.3314 mL
50 mM	0.0466 mL	0.2331 mL	0.4663 mL

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