Description：

AZD4547 is a novel selective FGFR inhibitor targeting FGFR1/2/3 with IC50 of 0.2 nM/2.5 nM/1.8 nM in cell-free assays, weaker activity against FGFR4, VEGFR2(KDR), and little activity observed against IGFR, CDK2, and p38. Phase 2/3.

Chemical Information：

Molecular Weight (MW)		463.57
Formula		C26H33N5O3
CAS No.		1035270-39-3
Solubility (25°C) *	DMSO	92 mg/mL (198.45 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

HSP90β 58 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1572 mL	10.7859 mL	21.5717 mL
5 mM	0.4314 mL	2.1572 mL	4.3143 mL
10 mM	0.2157 mL	1.0786 mL	2.1572 mL
50 mM	0.0431 mL	0.2157 mL	0.4314 mL

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