Description：

TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.

Chemical Information：

Molecular Weight (MW)		295.17
Formula		C13H12Cl2N4
CAS No.		1609960-31-7
Solubility (25°C) *	DMSO	20 mg/mL warmed (67.75 mM)
	Water	Insoluble
	Alcohol	1 mg/mL warmed (3.38 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	3.3879 mL	16.9394 mL	33.8788 mL
5 mM	0.6776 mL	3.3879 mL	6.7758 mL
10 mM	0.3388 mL	1.6939 mL	3.3879 mL
50 mM	0.0678 mL	0.3388 mL	0.6776 mL

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