Description：

TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism.

Chemical Information：

Molecular Weight (MW)		449.04
Formula		C9H16Br2N5O4P
CAS No.		918633-87-1
Solubility (25°C) *	DMSO	90 mg/mL (200.42 mM)
	Water	10 mg/mL warmed (22.26 mM)
	Alcohol	90 mg/mL (200.42 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2270 mL	11.1349 mL	22.2697 mL
5 mM	0.4454 mL	2.2270 mL	4.4539 mL
10 mM	0.2227 mL	1.1135 mL	2.2270 mL
50 mM	0.0445 mL	0.2227 mL	0.4454 mL

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