Description：

TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1.

Chemical Information：

Molecular Weight (MW)		547.96
Formula		C26H25ClF3N5O3
CAS No.		871026-44-7
Solubility (25°C) *	DMSO	110 mg/mL (200.74 mM)
	Water	Insoluble
	Alcohol	54 mg/mL (98.54 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.8250 mL	9.1248 mL	18.2495 mL
5 mM	0.3650 mL	1.8250 mL	3.6499 mL
10 mM	0.1825 mL	0.9125 mL	1.8250 mL
50 mM	0.0365 mL	0.1825 mL	0.3650 mL

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