Description：

abemaciclib (LY2835219) is a potent and selective inhibitor of CDK4 and CDK6 with IC50 of 2 nM and 10 nM in cell-free assays, respectively. Phase 3.

Chemical Information：

Molecular Weight (MW)		602.7
Formula		C27H32F2N8.CH4O3S
CAS No.		1231930-82-7
Solubility (25°C) *	DMSO	83 mg/mL (137.71 mM)
	Water	100 mg/mL (165.92 mM)
	Alcohol	24 mg/mL (39.82 mM)

Biological Activity：

Targets IC50

HDAC (MOLT-4 cel HDAC (Reh cells 5 nM 20 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.6592 mL	8.2960 mL	16.5920 mL
5 mM	0.3318 mL	1.6592 mL	3.3184 mL
10 mM	0.1659 mL	0.8296 mL	1.6592 mL
50 mM	0.0332 mL	0.1659 mL	0.3318 mL

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