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Description:
Staurosporine is a potent PKC inhibitor for PKCα, PKCγ and PKCη with IC50 of 2 nM, 5 nM and 4 nM, less potent to PKCδ (20 nM), PKCε (73 nM) and little active to PKCζ (1086 nM) in cell-free assays. Also shows inhibitory activities on other kinases, such as PKA, PKG, S6K, CaMKII, etc. Phase 3.
Chemical Information:
Molecular Weight (MW) 466.53 Formula
C28H26N4O3
CAS No. 62996-74-1 Solubility (25°C) * DMSO 4 mg/mL (8.57 mM) Water Insoluble Alcohol Insoluble
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg 1 mM 2.1435 mL 10.7174 mL 21.4348 mL 5 mM 0.4287 mL 2.1435 mL 4.2870 mL 10 mM 0.2143 mL 1.0717 mL 2.1435 mL 50 mM 0.0429 mL 0.2143 mL 0.4287 mL
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