Description：

SIS3, a novel specific inhibitor of Smad3, inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways.

Chemical Information：

Molecular Weight (MW)		489.99
Formula		C28H27N3O3.HCl
CAS No.		521984-48-5
Solubility (25°C) *	DMSO	97 mg/mL (197.96 mM)
	Water	Insoluble
	Alcohol	24 mg/mL (48.98 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0409 mL	10.2043 mL	20.4086 mL
5 mM	0.4082 mL	2.0409 mL	4.0817 mL
10 mM	0.2041 mL	1.0204 mL	2.0409 mL
50 mM	0.0408 mL	0.2041 mL	0.4082 mL

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