Description：

ABC294640 is an orally bioavailable and selective sphingosine kinase-2 (SphK2) inhibitor with IC50 of approximately 60 μM. Phase 1/2.

Chemical Information：

Molecular Weight (MW)		380.91
Formula		C23H25ClN2O
CAS No.		915385-81-8
Solubility (25°C) *	DMSO	76 mg/mL warmed (199.52 mM)
	Water	Insoluble
	Alcohol	28 mg/mL (73.5 mM)

Biological Activity：

Targets IC50

TNF-α 13 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.6253 mL	13.1265 mL	26.2529 mL
5 mM	0.5251 mL	2.6253 mL	5.2506 mL
10 mM	0.2625 mL	1.3126 mL	2.6253 mL
50 mM	0.0525 mL	0.2625 mL	0.5251 mL

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