Description：

AZ628 is a new pan-Raf inhibitor for BRAF, BRAFV600E, and c-Raf-1 with IC50 of 105 nM, 34 nM and 29 nM in cell-free assays, also inhibits VEGFR2, DDR2, Lyn, Flt1, FMS, etc.

Chemical Information：

Molecular Weight (MW)		451.52
Formula		C27H25N5O2
CAS No.		878739-06-1
Solubility (25°C) *	DMSO	90 mg/mL (199.32 mM)
	Water	Insoluble
	Alcohol	Insoluble

Biological Activity：

Targets IC50

HPDE4 LPDE4 120 nM 100 nM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2147 mL	11.0737 mL	22.1474 mL
5 mM	0.4429 mL	2.2147 mL	4.4295 mL
10 mM	0.2215 mL	1.1074 mL	2.2147 mL
50 mM	0.0443 mL	0.2215 mL	0.4429 mL

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