Description：

Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, also inhibits Notch signaling with IC50 of 14.1 nM in H4 human glioma cell. Phase 3.

Chemical Information：

Molecular Weight (MW)		361.44
Formula		C19H27N3O4
CAS No.		425386-60-3
Solubility (25°C) *	DMSO	72 mg/mL (199.2 mM)
	Water	Insoluble
	Alcohol	41 mg/mL (113.43 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.7667 mL	13.8336 mL	27.6671 mL
5 mM	0.5533 mL	2.7667 mL	5.5334 mL
10 mM	0.2767 mL	1.3834 mL	2.7667 mL
50 mM	0.0553 mL	0.2767 mL	0.5533 mL

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