Description：

SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of voltage dependence, exhibits >100-fold selectivity for TRPV1 over TRPM8. Phase 2.

Chemical Information：

Molecular Weight (MW)		429.23
Formula		C17H16BrF3N4O
CAS No.		501951-42-4
Solubility (25°C) *	DMSO	86 mg/mL (200.35 mM)
	Water	Insoluble
	Alcohol	20 mg/mL (46.59 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3298 mL	11.6488 mL	23.2975 mL
5 mM	0.4660 mL	2.3298 mL	4.6595 mL
10 mM	0.2330 mL	1.1649 mL	2.3298 mL
50 mM	0.0466 mL	0.2330 mL	0.4660 mL

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