Description：

Sapitinib (AZD8931) is a reversible, ATP competitive inhibitor of EGFR, ErbB2 and ErbB3 with IC50 of 4 nM, 3 nM and 4 nM in cell-free assays, more potent than Gefitinib or Lapatinib against NSCLC cell, 100-fold more selective for the ErbB family than MNK1 and Flt. Phase 2.

Chemical Information：

Molecular Weight (MW)		473.93
Formula		C23H25ClFN5O3
CAS No.		848942-61-0
Solubility (25°C) *	DMSO	40 mg/mL (84.4 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1100 mL	10.5501 mL	21.1002 mL
5 mM	0.4220 mL	2.1100 mL	4.2200 mL
10 mM	0.2110 mL	1.0550 mL	2.1100 mL
50 mM	0.0422 mL	0.2110 mL	0.4220 mL

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