Description：

Avadomide(CC-122), a new chemical entity termed pleiotropic pathway modifier, is a novel agent for Diffuse large B-cell lymphoma(DLBCL) with antitumor and immunomodulatory activity. Its molecular target is the protein cereblon (CRBN), a substrate receptor of the cullin ring E3 ubiquitin ligase complex CRL4^CRBN.

Chemical Information：

Molecular Weight (MW)		286.29
Formula		C14H14N4O3
CAS No.		1015474-32-4
Solubility (25°C) *	DMSO	57 mg/mL (199.09 mM)
	Water	Insoluble
	Alcohol	1 mg/mL (3.49 mM)

Biological Activity：

Targets IC50

HDAC8 HDAC6 HDAC3 1.46 μM 2.47 μM 16.9 μM

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	3.4930 mL	17.4648 mL	34.9296 mL
5 mM	0.6986 mL	3.4930 mL	6.9859 mL
10 mM	0.3493 mL	1.7465 mL	3.4930 mL
50 mM	0.0699 mL	0.3493 mL	0.6986 mL

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