Description：

S-Ruxolitinib is the chirality of INCB018424, which is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Phase 3.

Chemical Information：

Molecular Weight (MW)		306.37
Formula		C17H18N6
CAS No.		941685-37-6
Solubility (25°C) *	DMSO	61 mg/mL (199.1 mM)
	Water	5 mg/mL (16.32 mM)
	Alcohol	61 mg/mL (199.1 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	3.2640 mL	16.3201 mL	32.6403 mL
5 mM	0.6528 mL	3.2640 mL	6.5281 mL
10 mM	0.3264 mL	1.6320 mL	3.2640 mL
50 mM	0.0653 mL	0.3264 mL	0.6528 mL

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