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Description:
RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM,19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.
Chemical Information:
Molecular Weight (MW) 471.46 Formula
C21H18FN5O5S
CAS No. 946128-88-7 Solubility (25°C) * DMSO 94 mg/mL (199.38 mM) Water Insoluble Alcohol Insoluble
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg 1 mM 2.1211 mL 10.6054 mL 21.2107 mL 5 mM 0.4242 mL 2.1211 mL 4.2421 mL 10 mM 0.2121 mL 1.0605 mL 2.1211 mL 50 mM 0.0424 mL 0.2121 mL 0.4242 mL
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