Description：

Ripasudil (K-115) hydrochloride dihydrate is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.

Chemical Information：

Molecular Weight (MW)		395.88
Formula		C15H18FN3O2S.Cl H.2 H2 O
CAS No.		887375-67-9
Solubility (25°C) *	DMSO	26 mg/mL warmed (65.67 mM)
	Water	79 mg/mL (199.55 mM)
	Alcohol	5 mg/mL warmed (12.63 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.5260 mL	12.6301 mL	25.2602 mL
5 mM	0.5052 mL	2.5260 mL	5.0520 mL
10 mM	0.2526 mL	1.2630 mL	2.5260 mL
50 mM	0.0505 mL	0.2526 mL	0.5052 mL

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