Description：

Rigosertib (ON-01910) is a non-ATP-competitive inhibitor of PLK1 with IC50 of 9 nM in a cell-free assay. It shows 30-fold greater selectivity against Plk2 and no activity to Plk3. Phase 3.

Chemical Information：

Molecular Weight (MW)		473.47
Formula		C21H24NNaO8S
CAS No.		1225497-78-8
Solubility (25°C) *	DMSO	95 mg/mL (200.64 mM)
	Water	95 mg/mL (200.64 mM)
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1121 mL	10.5603 mL	21.1207 mL
5 mM	0.4224 mL	2.1121 mL	4.2241 mL
10 mM	0.2112 mL	1.0560 mL	2.1121 mL
50 mM	0.0422 mL	0.2112 mL	0.4224 mL

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