Description：

Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively. It shows greater than 1000-fold selectivity for HIV-1 IN over several related Mg2+-dependent enzyme such as HCV polymerase, HIV reverse transcriptase, HIV RNaseH and human α-, β-, γ-polymerases.

Chemical Information：

Molecular Weight (MW)		444.42
Formula		C20H21FN6O5
CAS No.		518048-05-0
Solubility (25°C) *	DMSO	88 mg/mL (198.01 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2501 mL	11.2506 mL	22.5012 mL
5 mM	0.4500 mL	2.2501 mL	4.5002 mL
10 mM	0.2250 mL	1.1251 mL	2.2501 mL
50 mM	0.0450 mL	0.2250 mL	0.4500 mL

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