Description：

RAF265 (CHIR-265) is a potent selective inhibitor of C-Raf/B-Raf/B-Raf V600E with IC50 of 3-60 nM, and exhibits potent inhibition on VEGFR2 phosphorylation with EC50 of 30 nM in cell-free assays. Phase 2.

Chemical Information：

Molecular Weight (MW)		518.41
Formula		C24H16F6N6O
CAS No.		927880-90-8
Solubility (25°C) *	DMSO	100 mg/mL (192.89 mM)
	Water	Insoluble
	Alcohol	33 mg/mL (63.65 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.9290 mL	9.6449 mL	19.2898 mL
5 mM	0.3858 mL	1.9290 mL	3.8580 mL
10 mM	0.1929 mL	0.9645 mL	1.9290 mL
50 mM	0.0386 mL	0.1929 mL	0.3858 mL

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