Description：

R406 (free base) is a potent Syk inhibitor with IC50 of 41 nM in a cell-free assay, strongly inhibits Syk but not Lyn, 5-fold less potent to Flt3. Phase 1.

Chemical Information：

Molecular Weight (MW)		470.45
Formula		C22H23FN6O5
CAS No.		841290-80-0
Solubility (25°C) *	DMSO	21 mg/mL (44.63 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1256 mL	10.6281 mL	21.2562 mL
5 mM	0.4251 mL	2.1256 mL	4.2512 mL
10 mM	0.2126 mL	1.0628 mL	2.1256 mL
50 mM	0.0425 mL	0.2126 mL	0.4251 mL

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