Description：

Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11; greater than 30-fold selectivity against HDACs 3, 5, 8, and 9 and lowest potency to HDACs 6 and 7. Phase 2.

Chemical Information：

Molecular Weight (MW)		467.39
Formula		C21H28Cl2N6O2
CAS No.		875320-31-3
Solubility (25°C) *	DMSO	79 mg/mL (169.02 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1395 mL	10.6977 mL	21.3954 mL
5 mM	0.4279 mL	2.1395 mL	4.2791 mL
10 mM	0.2140 mL	1.0698 mL	2.1395 mL
50 mM	0.0428 mL	0.2140 mL	0.4279 mL

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