Description：

AT406 (SM-406) is a potent Smac mimetic and an antagonist of IAP (inhibitor of apoptosis protein via E3 ubiquitin ligase), binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with K_i of 66.4 nM, 1.9 nM, and 5.1 nM, 50- to 100-fold higher affinities than the Smac AVPI peptide. Phase 1.

Chemical Information：

Molecular Weight (MW)		561.71
Formula		C32H43N5O4
CAS No.		1071992-99-8
Solubility (25°C) *	DMSO	100 mg/mL (178.02 mM)
	Water	Insoluble
	Alcohol	100 mg/mL (178.02 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.7803 mL	8.9014 mL	17.8028 mL
5 mM	0.3561 mL	1.7803 mL	3.5606 mL
10 mM	0.1780 mL	0.8901 mL	1.7803 mL
50 mM	0.0356 mL	0.1780 mL	0.3561 mL

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