Description：

AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with K_i of 0.32 μM, 0.48 μM and 0.18 μM in cell-free assays; does not inhibit BIR3 domain and BID. Phase 2.

Chemical Information：

Molecular Weight (MW)		578.61
Formula		C30H30O8.C2H4O2
CAS No.		866541-93-7
Solubility (25°C) *	DMSO	116 mg/mL (200.48 mM)
	Water	Insoluble
	Alcohol	89 mg/mL (153.81 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.7283 mL	8.6414 mL	17.2828 mL
5 mM	0.3457 mL	1.7283 mL	3.4566 mL
10 mM	0.1728 mL	0.8641 mL	1.7283 mL
50 mM	0.0346 mL	0.1728 mL	0.3457 mL

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