Description：

PHA-767491 is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM in cell-free assays, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.

Chemical Information：

Molecular Weight (MW)		249.7
Formula		C12H11N3O.HCl
CAS No.		942425-68-5
Solubility (25°C) *	DMSO	24 mg/mL (96.11 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	4.0048 mL	20.0240 mL	40.0481 mL
5 mM	0.8010 mL	4.0048 mL	8.0096 mL
10 mM	0.4005 mL	2.0024 mL	4.0048 mL
50 mM	0.0801 mL	0.4005 mL	0.8010 mL

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