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Description:
PF-562271 HCl is the hydrochloride salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs. Phase 1.
Chemical Information:
Molecular Weight (MW) 543.95 Formula
C21H21ClF3N7O3S
CAS No. 939791-41-0 Solubility (25°C) * DMSO 100 mg/mL (183.84 mM) Water Insoluble Alcohol Insoluble
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg 1 mM 1.8384 mL 9.1920 mL 18.3840 mL 5 mM 0.3677 mL 1.8384 mL 3.6768 mL 10 mM 0.1838 mL 0.9192 mL 1.8384 mL 50 mM 0.0368 mL 0.1838 mL 0.3677 mL
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