Description：

PF-477736 is a selective, potent and ATP-competitive Chk1 inhibitor with K_i of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2. Phase 1.

Chemical Information：

Molecular Weight (MW)		419.48
Formula		C22H25N7O2
CAS No.		952021-60-2
Solubility (25°C) *	DMSO	6 mg/mL (14.3 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.3839 mL	11.9195 mL	23.8390 mL
5 mM	0.4768 mL	2.3839 mL	4.7678 mL
10 mM	0.2384 mL	1.1920 mL	2.3839 mL
50 mM	0.0477 mL	0.2384 mL	0.4768 mL

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