Description：

PF 3716556 is a potent and selective P-CAB (potassium-competitive acid blocker), with pIC50 of 6.026 and 7.095 for the inhibition of porcine H⁺,K⁺-ATPase activity in ion-leaky and ion-tight assay, respectively, inhibits gastric acid secretion, displays no activity at Na⁺,K⁺-ATPase, used for the treatment of gastroesophageal reflux disease.

Chemical Information：

Molecular Weight (MW)		394.47
Formula		C22H26N4O3
CAS No.		928774-43-0
Solubility (25°C) *	DMSO	79 mg/mL (200.26 mM)
	Water	Insoluble
	Alcohol	79 mg/mL (200.26 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.5350 mL	12.6752 mL	25.3505 mL
5 mM	0.5070 mL	2.5350 mL	5.0701 mL
10 mM	0.2535 mL	1.2675 mL	2.5350 mL
50 mM	0.0507 mL	0.2535 mL	0.5070 mL

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