Description：

PD0325901 is a selective and non ATP-competitive MEK inhibitor with IC50 of 0.33 nM in cell-free assays, roughly 500-fold more potent than CI-1040 on phosphorylation of ERK1 and ERK2. Phase 2.

Chemical Information：

Molecular Weight (MW)		482.19
Formula		C16H14F3IN2O4
CAS No.		391210-10-9
Solubility (25°C) *	DMSO	96 mg/mL (199.09 mM)
	Water	Insoluble
	Alcohol	40 mg/mL (82.95 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0739 mL	10.3694 mL	20.7387 mL
5 mM	0.4148 mL	2.0739 mL	4.1477 mL
10 mM	0.2074 mL	1.0369 mL	2.0739 mL
50 mM	0.0415 mL	0.2074 mL	0.4148 mL

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