Description：

Osimertinib (AZD9291) is an oral, irreversible, and mutant-selective EGFR inhibitor with IC50 of 12.92, 11.44 and 493.8 nM for Exon 19 deletion EGFR, L858R/T790M EGFR, and WT EGFR in LoVo cells, respectively. Phase 3.

Chemical Information：

Molecular Weight (MW)		499.61
Formula		C28 H33 N7 O2
CAS No.		1421373-65-0
Solubility (25°C) *	DMSO	99 mg/mL warmed (198.15 mM)
	Water	Insoluble
	Alcohol	43 mg/mL warmed (86.06 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.0016 mL	10.0078 mL	20.0156 mL
5 mM	0.4003 mL	2.0016 mL	4.0031 mL
10 mM	0.2002 mL	1.0008 mL	2.0016 mL
50 mM	0.0400 mL	0.2002 mL	0.4003 mL

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