Description：

Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met. Phase 3.

Chemical Information：

Molecular Weight (MW)		557.04
Formula		C30H29ClN6O3
CAS No.		698387-09-6
Solubility (25°C) *	DMSO	5 mg/mL warmed (8.97 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	1.7952 mL	8.9760 mL	17.9520 mL
5 mM	0.3590 mL	1.7952 mL	3.5904 mL
10 mM	0.1795 mL	0.8976 mL	1.7952 mL
50 mM	0.0359 mL	0.1795 mL	0.3590 mL

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