Description：

Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM in BT-474 cell; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk in BT-474 cell line. Phase 1.

Chemical Information：

Molecular Weight (MW)		468.47
Formula		C25H23F3N4O2
CAS No.		366017-09-6
Solubility (25°C) *	DMSO	13 mg/mL (27.74 mM)
	Water	Insoluble
	Alcohol	Insoluble

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.1346 mL	10.6730 mL	21.3461 mL
5 mM	0.4269 mL	2.1346 mL	4.2692 mL
10 mM	0.2135 mL	1.0673 mL	2.1346 mL
50 mM	0.0427 mL	0.2135 mL	0.4269 mL

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