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3-Methyladenine (3-MA)

3-Methyladenine (3-MA)

Catalog Number: CC2923 Rank: comment rank 5

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Description:

3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM in HeLa cells; blocks class I PI3K consistently, whereas suppression of class III PI3K is transient, and also blocks autophagosome formation.

Chemical Information:

Molecular Weight (MW) 149.15
Formula

 

C6H7N5

 

CAS No. 5142-23-4
Solubility (25°C) * DMSO 3 mg/mL warmed (20.11 mM)
Water 10 mg/mL warmed (67.04 mM)
Alcohol 4 mg/mL (26.81 mM)


Preparing Stock Solutions

Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 6.7047 mL 33.5233 mL 67.0466 mL
5 mM 1.3409 mL 6.7047 mL 13.4093 mL
10 mM 0.6705 mL 3.3523 mL 6.7047 mL
50 mM 0.1341 mL 0.6705 mL 1.3409 mL


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