Description：

LY2874455 is a pan-FGFR inhibitor with IC50 of 2.8 nM, 2.6 nM, 6.4 nM, and 6 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively, and also inhibits VEGFR2 activity with IC50 of 7 nM. Phase 1.

Chemical Information：

Molecular Weight (MW)		444.31
Formula		C21H19Cl2N5O2
CAS No.		1254473-64-7
Solubility (25°C) *	DMSO	88 mg/mL (198.05 mM)
	Water	Insoluble
	Alcohol	57 mg/mL warmed (128.28 mM)

Preparing Stock Solutions

Concentration Volume (DMSO) Mass	1 mg	5 mg	10 mg
1 mM	2.2507 mL	11.2534 mL	22.5068 mL
5 mM	0.4501 mL	2.2507 mL	4.5014 mL
10 mM	0.2251 mL	1.1253 mL	2.2507 mL
50 mM	0.0450 mL	0.2251 mL	0.4501 mL

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