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Description:
Lomibuvir (VX-222, VCH-222) is a novel, potent and selective inhibitor of HCV polymerase with IC50 of 0.94-1.2 μM, 15.3-fold less effective for mutant M423T, and 108-fold less effective for mutant I482L. Phase 2.
Chemical Information:
Molecular Weight (MW) 445.61 Formula
C25H35NO4S
CAS No. 1026785-59-0 Solubility (25°C) * DMSO 89 mg/mL (199.72 mM) Water Insoluble Alcohol 89 mg/mL (199.72 mM)
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg 1 mM 2.2441 mL 11.2206 mL 22.4411 mL 5 mM 0.4488 mL 2.2441 mL 4.4882 mL 10 mM 0.2244 mL 1.1221 mL 2.2441 mL 50 mM 0.0449 mL 0.2244 mL 0.4488 mL
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